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@media(prefers-reduced-motion:reduce){html{scroll-behavior:auto}*,*:before,*:after{transition:none!important;animation:none!important}}

.approach a:focus-visible,.approach button:focus-visible,.approach [tabindex]:focus-visible{outline-color:#f0c6a8}.approach .mechanism-panel button:focus-visible{outline-color:#9b482f}

/* Cinematic opening, preserving the existing identity. */
.hero-cinematic{display:block;width:calc(100% - 48px);max-width:1550px;margin:20px auto 42px;padding:0;min-height:665px;height:min(780px,calc(100svh - 130px));position:relative;isolation:isolate;overflow:hidden;border-radius:5px;background:#251422;color:#fff7f0}
.hero-cinematic .hero-art{position:absolute;inset:0;height:100%;width:100%;border-radius:0;background:#251422;z-index:-3}
.hero-cinematic .hero-art>img{width:100%;height:100%;object-fit:cover;object-position:center;animation:cell-drift 26s ease-in-out infinite alternate;will-change:transform}
.hero-shade{position:absolute;inset:0;z-index:-2;background:linear-gradient(90deg,rgba(28,13,25,.66),rgba(32,15,28,.34) 43%,transparent 72%),linear-gradient(0deg,rgba(22,9,21,.6),transparent 25%)}
.hero-cinematic .hero-copy{padding:76px 52px 110px;position:relative;max-width:760px}
.hero-cinematic .eyebrow{color:#ebd0dd;font-size:9px;letter-spacing:.13em}.hero-cinematic .status-dot{background:#d8a9ba}
.hero-cinematic h1{font-size:clamp(63px,6.5vw,94px);letter-spacing:-3.9px;margin:32px 0 27px;line-height:1.01}.hero-cinematic h1 em{color:#e9bdcc;font-size:1.12em}
.hero-cinematic .hero-copy>p{color:#e1d4dc;max-width:380px;font-size:14px;line-height:1.8}.hero-cinematic .button{margin-top:28px}
.button-cinema{background:#f8f5ee;color:#4e293f}.button-cinema:hover{background:#e9d5de}
.hero-cinematic .hero-art figcaption{color:#e3ccd6;font-size:8px;right:24px;bottom:15px;z-index:3}
.hero-film-footer{position:absolute;bottom:48px;left:52px;right:36px;display:flex;align-items:center;gap:30px;font-size:8px;letter-spacing:.14em;color:#ddc5d1}
.scroll-cue{display:inline-flex;align-items:center;gap:14px}.scroll-cue>span{font-size:20px}.film-label{margin-left:auto;font-size:7px;letter-spacing:.15em}
#motion-toggle{display:inline-flex;gap:10px;align-items:center;border:1px solid #c3a2b173;border-radius:3px;color:#f1dde7;padding:9px 11px;font-size:9px;letter-spacing:0;background:#301b2b38}.motion-icon{font-size:11px}
.motion-paused .hero-art>img{animation-play-state:paused}.motion-paused .scroll-cue>span{animation-play-state:paused}
@keyframes cell-drift{from{transform:scale(1.01) translateX(0)}to{transform:scale(1.065) translateX(-.8%)}}
.legend-payload{background:#d49a51;border-radius:1px!important;transform:rotate(30deg)}
.adc-anatomy{display:grid;grid-template-columns:.8fr 1.3fr;gap:48px;padding-top:48px;margin-top:50px;border-top:1px solid #795b6e;align-items:center}.adc-anatomy-copy .eyebrow{font-size:8px;color:#dac1ce;margin-bottom:18px}.adc-anatomy h3{font-size:31px;line-height:1.15;letter-spacing:-.7px;margin-bottom:18px}.adc-anatomy h3 em{color:#e4b9c8;font-size:1.15em}.adc-anatomy-copy>p{font-size:12px;line-height:1.8;color:#ddcbd5;max-width:330px}.adc-anatomy-copy .adc-detail-note{font-size:9px;line-height:1.8;color:#c8b5c0;margin-top:15px}.adc-detail-figure{background:#efe9e0;border-radius:4px;padding:24px 18px 18px}.adc-detail{width:100%;height:auto}.adc-detail-figure figcaption{color:#6b5361;font-size:10px;text-align:center;padding:12px 0 0}.figure-note{max-width:100%;margin-top:25px;text-align:left}
.team{border-top:1px solid var(--line)}.team-heading{display:grid;grid-template-columns:1.6fr 1fr;gap:70px;align-items:end}.team-heading h2{font-size:clamp(36px,4.2vw,59px)}.team-heading>p{color:var(--muted);font-size:14px;line-height:1.8;max-width:300px;justify-self:end}.team-grid{display:grid;grid-template-columns:repeat(4,minmax(0,1fr));gap:25px;margin-top:50px}.team-portrait{aspect-ratio:1.1;overflow:hidden;background:#e9e4df;border-radius:3px}.team-portrait img{width:100%;height:100%;object-fit:cover;object-position:center 35%;transition:transform .7s}.team-member:hover .team-portrait img{transform:scale(1.035)}.team-member h3{font-size:21px;margin-top:21px;line-height:1.2;letter-spacing:-.6px}.team-role{font-size:10px;color:#865169;margin-top:8px;line-height:1.5;min-height:30px}.team-bio{font-size:12px;line-height:1.8;color:var(--muted);padding-top:15px;border-top:1px solid var(--line);margin-top:12px}.team-member-liqin .team-portrait img{object-position:center 25%}
@media(min-width:1500px){.hero-cinematic .hero-copy{padding-left:75px;padding-top:90px}.hero-film-footer{left:75px}}
@media(max-width:1050px){#primary-nav{gap:24px}.hero-cinematic{min-height:630px}.hero-cinematic .hero-copy{padding:65px 38px 110px}.hero-cinematic h1{font-size:65px}.hero-film-footer{left:38px;right:25px}.film-label{display:none}#motion-toggle{margin-left:auto}.team-heading{gap:35px}.team-grid{gap:18px}.team-member h3{font-size:18px}.adc-anatomy{gap:28px}.adc-anatomy h3{font-size:28px}}
@media(max-width:760px){.hero-cinematic{width:calc(100% - 24px);min-height:780px;height:auto;margin:12px auto 30px}.hero-cinematic .hero-copy{padding:40px 24px 285px}.hero-cinematic h1{font-size:clamp(48px,11.5vw,72px);letter-spacing:-2.5px;margin-top:27px}.hero-cinematic h1 em{letter-spacing:-1.7px}.hero-cinematic .eyebrow{font-size:7px;letter-spacing:.09em}.hero-cinematic .hero-copy>p{font-size:13px;max-width:335px}.hero-cinematic .hero-art>img{width:205%;max-width:none;height:100%;object-fit:cover;object-position:62% center;position:absolute;right:-18%;opacity:.7}.hero-shade{background:linear-gradient(180deg,rgba(29,13,26,.88),rgba(29,13,26,.68) 48%,rgba(29,13,26,.05) 74%,rgba(29,13,26,.5)),linear-gradient(90deg,rgba(29,13,26,.2),transparent)}.hero-film-footer{left:24px;right:20px;bottom:42px;font-size:7px;gap:15px}.scroll-cue{gap:9px}.hero-cinematic .hero-art figcaption{right:20px;font-size:7px;bottom:12px}#motion-toggle{font-size:8px;padding:8px}.adc-anatomy{grid-template-columns:1fr;gap:24px;margin-top:30px;padding-top:30px}.adc-anatomy h3 br{display:none}.adc-anatomy h3{font-size:27px;line-height:1.2}.adc-anatomy h3 em{display:block}.adc-anatomy-copy>p{max-width:none}.adc-detail-figure{padding:15px 3px}.adc-detail-figure figcaption{font-size:8px;padding-inline:10px}.team-heading{grid-template-columns:1fr;gap:24px}.team-heading h2{font-size:39px}.team-heading>p{justify-self:start;font-size:13px;max-width:330px}.team-grid{grid-template-columns:1fr 1fr;gap:35px 18px;margin-top:33px}.team-member h3{font-size:18px;line-height:1.3;margin-top:15px}.team-role{font-size:9px;min-height:30px}.team-bio{font-size:14px;line-height:1.65}.team-portrait{aspect-ratio:.9}.diagram-legend{gap:12px}.hero-cinematic a:focus-visible,.hero-cinematic button:focus-visible{outline-color:#f0c6a8}}
@media(max-width:380px){.team-grid{grid-template-columns:1fr}.team-portrait{aspect-ratio:1.2}.team-role{min-height:0}.hero-cinematic .hero-copy{padding-inline:20px}}
@media(prefers-reduced-motion:reduce){.hero-cinematic .hero-art>img{animation:none;transform:none;will-change:auto}#motion-toggle{display:none}}
@media(max-width:760px){.adc-detail text{font-size:18px}}

/* Chemotherapy and senescence lead into the ADC concept. */
.science.section-pad{padding-block:148px}
.science .section-kicker{font-size:11px;line-height:1.7;margin-bottom:56px;gap:24px}
.science-intro{align-items:start;gap:clamp(56px,7vw,108px)}
.science-description .large-copy{font-size:25px;line-height:1.55;letter-spacing:-.45px;max-width:590px}
.science-description>p+p{font-size:16px;line-height:1.75;margin-top:26px;max-width:590px}
.science-description .text-link{font-size:13px;margin-top:30px}
.science .science-points{margin-top:96px;gap:48px}
.science-points article{padding-top:30px}
.science .point-index{font-size:11px}
.science-points h3{font-size:24px;line-height:1.3;margin:26px 0 16px;letter-spacing:-.5px}
.science-points p{font-size:15px;line-height:1.75;max-width:340px}
.science-bridge{display:flex;gap:23px;align-items:flex-start;margin-top:42px;padding-top:28px;border-top:1px solid var(--line)}
.science .science-bridge{margin-top:64px;padding-top:36px}
.bridge-mark{color:var(--plum);font-size:31px;line-height:1}
.science-bridge p{max-width:780px;color:var(--muted);font-size:15px;line-height:1.8}
.science .science-bridge p{max-width:900px;font-size:17px;line-height:1.7}
.science-bridge strong{color:var(--ink);font-weight:500}
.research-outlook{padding-block:74px}
.research-outlook .vision-heading{grid-template-columns:1fr 1.25fr;align-items:start;gap:90px}
.research-outlook h2{font-size:clamp(33px,3.5vw,46px)}
.outlook-copy>p{font-size:14px;line-height:1.8;color:var(--muted);max-width:620px}
.outlook-copy>p+p{margin-top:15px}
.outlook-copy .research-note{font-size:11px;text-align:left;margin-top:20px}
@media(max-width:760px){.science-bridge{margin-top:30px;gap:15px}.science-bridge p{font-size:13px}.research-outlook{padding-block:55px}.research-outlook .vision-heading{grid-template-columns:1fr;gap:25px}.research-outlook h2{font-size:34px}.outlook-copy>p{font-size:13px}}
@media(max-width:1050px){
  .science.section-pad{padding-block:112px}
  .science .section-kicker{margin-bottom:44px}
  .science-intro{gap:48px}
  .science-description .large-copy{font-size:23px}
  .science .science-points{gap:28px;margin-top:76px}
  .science-points h3{font-size:22px}
  .science-points p{font-size:14px}
}
@media(max-width:760px){
  .science.section-pad{padding-block:84px}
  .science .section-kicker{font-size:10px;gap:18px;margin-bottom:34px}
  .science-intro{gap:34px}
  .science-description .large-copy{font-size:20px;line-height:1.55;letter-spacing:-.3px}
  .science-description>p+p{font-size:14px;line-height:1.75;margin-top:22px}
  .science-description .text-link{font-size:12px;margin-top:26px}
  .science .science-points{gap:34px;margin-top:56px}
  .science-points article{padding-top:23px;column-gap:18px}
  .science-points h3{font-size:21px;margin:0 0 12px}
  .science-points p{max-width:none;font-size:14px}
  .science .science-bridge{margin-top:44px;padding-top:30px;gap:16px}
  .science .science-bridge p{font-size:15px;line-height:1.75}
}

/* The synergy diagram is self-contained; activity buttons control data-emphasis. */
.synergy{margin-top:56px;color:#f8f5ee}
.synergy-intro{display:grid;grid-template-columns:1fr 1fr;align-items:end;gap:64px;margin-bottom:30px}
.synergy-intro .eyebrow{font-size:9px;letter-spacing:.12em;color:#dec0ce;margin-bottom:17px}
.synergy-intro h3{font-size:clamp(31px,3.1vw,43px);line-height:1.13;letter-spacing:-1.1px}
.synergy-intro h3 em{color:#e4b9c8;font-size:1.08em}
.synergy-intro>p{font-size:14px;line-height:1.8;color:#ddcbd5;max-width:430px}
.synergy-figure{background:#f2ece4;border:1px solid #e7dacf;border-radius:5px;padding:26px 30px 22px;color:#4e293f;overflow:hidden}
.synergy-diagram-top{display:flex;justify-content:flex-end;align-items:center;gap:20px;color:#705c67;font-size:9px;letter-spacing:.09em;line-height:1.5}
.synergy-cell-key{display:inline-flex;align-items:center;gap:12px;letter-spacing:0;font-size:clamp(15px,1.6vw,18px);line-height:1.25;margin-right:8px}
.synergy-cell-key i{width:.55em;height:.55em;background:#d9bfcb;border:1px solid #b68ca2;border-radius:50%;flex-shrink:0}
.synergy-diagram-wrap{position:relative;width:100%;max-width:760px;margin:12px auto 0;container-type:inline-size}
.synergy-diagram{display:block;width:100%;height:auto;overflow:visible}
.synergy-cell-intact,.synergy-cell-death,.synergy-cell-death-label{transition:opacity .45s ease;pointer-events:none}
.synergy-cell-death,.synergy-cell-death-label{opacity:0}
.synergy[data-emphasis="both"] .synergy-cell-intact{opacity:0}
.synergy[data-emphasis="both"] .synergy-cell-death,.synergy[data-emphasis="both"] .synergy-cell-death-label{opacity:1}
/* Compensate for SVG scaling to keep all three labels readable on phones. */
.synergy-component-labels,.synergy-cell-death-label{font-family:DM Sans,Arial,sans-serif;font-size:max(24px,calc(66px - 8.8cqw));font-weight:400;fill:#654358}
.synergy-cell-death-label{font-size:max(22px,calc(61px - 8.1cqw))}
.synergy-diagram-control{position:absolute;width:6.315789%;min-width:44px;min-height:44px;aspect-ratio:1;border:2px solid transparent;border-radius:50%;padding:0;background:transparent;transform:translate(-50%,-50%);touch-action:manipulation;cursor:pointer}
.synergy-diagram-control-antibody{left:29.342105%;top:60.434783%}
.synergy-diagram-control-payload{left:60.657895%;top:58.260870%}
.synergy-diagram-control-combined{left:48.421053%;top:78.043478%;width:10%}
.synergy-diagram-control:hover{border-color:#4e293f}
.synergy .synergy-diagram-control:focus-visible{outline:3px solid #4e293f;outline-offset:4px}
.synergy-diagram .antibody-action,.synergy-diagram .payload-action,.synergy-diagram .combined-action{transition:opacity .25s ease}
.synergy[data-emphasis="antibody"] .payload-action,.synergy[data-emphasis="payload"] .antibody-action{opacity:.15}
.synergy[data-emphasis="antibody"] .combined-action,.synergy[data-emphasis="payload"] .combined-action{opacity:.42}
.synergy-activities{display:grid;grid-template-columns:1fr 1fr 1.12fr;gap:12px;margin-top:16px}
.synergy-activity{font:inherit;display:flex;gap:11px;text-align:left;align-items:flex-start;border:1px solid #d6c6cb;background:#f6f0e9;color:#4e293f;padding:17px 15px 18px;border-radius:3px;cursor:pointer;transition:border-color .2s,background .2s,box-shadow .2s;min-width:0}
.synergy-activity:hover{background:#fcf8f1;border-color:#ad899a}
.synergy-activity[aria-pressed="true"]{background:#fff9f1;border-color:#6e435c;box-shadow:inset 0 -3px 0 #6e435c}
.synergy-activity:focus-visible{outline:3px solid #98506d!important;outline-offset:4px}
.synergy-activity-number{font-size:12px;line-height:25px;flex:0 0 25px;width:25px;height:25px;border-radius:50%;text-align:center;color:#fff8f3;background:#96516e}
.synergy-activity-payload .synergy-activity-number{background:#8a652c}
.synergy-activity-combined .synergy-activity-number{background:#4e293f}
.synergy-activity-copy{display:flex;flex-direction:column;gap:8px;min-width:0}
.synergy-activity-copy strong{font-size:17px;font-weight:500;letter-spacing:-.2px;line-height:1.6}
.synergy-activity-copy>span{color:#725b67;font-size:14px;line-height:1.65}
.synergy-figure figcaption{font-size:10px;line-height:1.7;color:#7d6873;margin-top:18px;max-width:710px}
.synergy .sr-only{position:absolute;width:1px;height:1px;padding:0;margin:-1px;overflow:hidden;clip:rect(0,0,0,0);white-space:nowrap;border:0}
@media(max-width:1050px){.synergy-intro{gap:35px}.synergy-figure{padding:23px 22px 20px}.synergy-activities{gap:9px}.synergy-activity{padding:14px 12px;gap:8px}}
@media(max-width:760px){.synergy{margin-top:36px}.synergy-intro{grid-template-columns:1fr;gap:20px;margin-bottom:24px}.synergy-intro .eyebrow{font-size:8px}.synergy-intro h3{font-size:34px}.synergy-intro>p{font-size:13px;max-width:none}.synergy-figure{padding:20px 16px 18px}.synergy-diagram-top{flex-wrap:wrap;gap:10px;font-size:8px}.synergy-diagram-wrap{width:calc(100% + 28px);max-width:none;margin:15px -14px 0}.synergy-activities{grid-template-columns:1fr;margin-top:18px;gap:9px}.synergy-activity{padding:15px 14px;gap:12px}.synergy-activity-copy{gap:5px}.synergy-activity-number{font-size:13px;line-height:27px;flex-basis:27px;width:27px;height:27px}.synergy-figure figcaption{font-size:10px;margin-top:17px}}
@media(prefers-reduced-motion:reduce){.synergy-diagram .antibody-action,.synergy-diagram .payload-action,.synergy-diagram .combined-action,.synergy-activity,.synergy-cell-intact,.synergy-cell-death,.synergy-cell-death-label{transition:none}}

.synergy-instruction{font-size:13px;color:#705c67;margin:32px 0 0}
.synergy-instruction+.synergy-activities{margin-top:10px}

/* Keep the closing sections spacious, with slightly tighter Vision edges. */
.team.section-pad{
  min-height:calc(100svh - 68px);
  padding-block:clamp(72px,9svh,112px);
}
.research-outlook{
  min-height:calc(100svh - 68px - clamp(28px,3.6svh,44px));
  padding-block:clamp(58px,7.2svh,90px);
}
.research-outlook,.team.section-pad{
  display:flex;
  flex-direction:column;
  justify-content:center;
}
.research-outlook h2{font-size:clamp(42px,4.3vw,61px)}
.research-outlook .outlook-copy>p{font-size:clamp(17px,1.6vw,22px);line-height:1.7}
.research-outlook .vision-heading{grid-template-columns:1.1fr 1fr;align-items:center;gap:64px}
#science,#vision,#team,#contact{scroll-margin-top:-16px}
.contact .contact-inner{padding-block:136px}
.team .team-grid{margin-top:64px}
/* Individual crops keep the original portraits at a comparable face scale. */
.team .team-portrait{aspect-ratio:1.1}
.team .team-member .team-portrait img{
  object-position:var(--portrait-x,50%) 50%;
  transform:translateY(var(--portrait-shift,0%)) scale(var(--portrait-zoom,1));
}
.team .team-member:hover .team-portrait img{
  transform:translateY(var(--portrait-shift,0%)) scale(calc(var(--portrait-zoom,1) * 1.035));
}
.team-member-rene{--portrait-x:25%}
.team-member-liqin{--portrait-x:0%;--portrait-zoom:1.15;--portrait-shift:-3%}
.team-member-rolf{--portrait-x:40%}
.team-member-bas{--portrait-x:10%}
@media(max-width:760px){
  .team.section-pad{
    min-height:calc(100svh - 60px);
    padding-block:72px;
  }
  .research-outlook{
    min-height:calc(100svh - 88px);
    padding-block:58px;
  }
  .research-outlook h2{font-size:40px}
  .research-outlook .vision-heading{grid-template-columns:1fr;gap:28px}
  .research-outlook .outlook-copy>p{font-size:18px}
  .contact .contact-inner{padding-block:111px}
  .team .team-grid{margin-top:44px}
}

/* Findings and their sources stay together in the research panel. */
#evidence-dialog{width:min(780px,calc(100vw - 32px))}
#evidence-dialog>p{font-size:14px}
.reference-list li{padding-block:23px}
.reference-list li>span{font-size:9px;color:var(--rose);margin-bottom:10px}
.reference-list h3{font-size:22px;line-height:1.3;letter-spacing:-.5px}
.reference-list p{font-size:14px;line-height:1.7;color:var(--muted)}
.reference-sources{display:flex;flex-wrap:wrap;gap:10px 24px;margin-top:14px}
.reference-sources a{display:inline-flex;align-items:center;gap:12px;font-size:12px;color:var(--plum);border-bottom:1px solid #b4a3ac;padding-bottom:3px}
@media(max-width:480px){
  #evidence-dialog{padding:25px 22px}
  #evidence-dialog h2{font-size:36px}
  .reference-list h3{font-size:21px}
}

/* Center the complete schematic while keeping its labels left-aligned. */
.vision-pathway{--vision-goal-size:32px;--vision-goal-leading:1.23;--vision-goal-tracking:-.7px;position:relative;top:48px;width:100%;max-width:1040px;margin:40px auto 0;padding:20px 0 10px;color:#4e293f}
.vision-pathway>figcaption{text-align:center;font-family:'DM Sans',Arial,sans-serif;font-size:28px;line-height:1.3;letter-spacing:-.55px}
.vision-pathway>figcaption em{font-family:'Instrument Serif',Georgia,serif;font-size:1.25em;font-weight:400;color:#98556a}
.vision-pathway-map{display:grid;grid-template-columns:max-content 104px max-content;width:max-content;max-width:100%;align-items:center;min-height:280px;margin:32px auto 0}
.vision-pathway-source{display:flex;align-items:center;gap:24px;min-width:0;padding-right:22px}
.vision-pathway-cell{display:block;width:198px;height:auto;flex:0 0 198px}
.vision-pathway-source-copy{min-width:0}
.vision-pathway-label{display:block;font-family:'DM Sans',Arial,sans-serif;font-size:11px;font-weight:500;letter-spacing:.13em;line-height:1.5;color:#8a6073}
.vision-pathway-source-copy>p{font-family:'DM Sans',Arial,sans-serif;font-size:var(--vision-goal-size);line-height:var(--vision-goal-leading);letter-spacing:var(--vision-goal-tracking);margin:11px 0 9px;color:#4e293f}
.vision-pathway-context{display:block;font-size:14px;line-height:1.5;color:#796b71}
.vision-pathway-connector{height:auto;min-height:280px;width:100%;align-self:stretch}
.vision-pathway-connector svg{display:block;width:100%;height:100%;overflow:visible}
.vision-pathway-connector .vision-pathway-fork-mobile{display:none}
.vision-pathway-goals{display:grid;grid-template-rows:1fr 1fr;min-height:280px}
.vision-pathway-goal{display:flex;align-items:center;gap:20px;padding:16px 0;min-width:0}
.vision-pathway-node{display:block;flex:0 0 14px;width:14px;height:14px;border:1px solid #a87389;border-radius:50%;background:#ead8df;box-shadow:0 0 0 5px #f8f5ee}
.vision-pathway-goal h3{margin:9px 0 0;font-family:'DM Sans',Arial,sans-serif;font-size:var(--vision-goal-size);font-weight:400;letter-spacing:var(--vision-goal-tracking);line-height:var(--vision-goal-leading);color:#4e293f}
.vision-pathway-goal-burden .vision-pathway-node{border-color:#a1845f;background:#e8ddcc}
.vision-pathway-goal-burden .vision-pathway-label{color:#8a7153}
@media(max-width:1050px){
  .vision-pathway{--vision-goal-size:30px}
  .vision-pathway-map{grid-template-columns:max-content 88px max-content}
  .vision-pathway-source{gap:20px;padding-right:18px}
  .vision-pathway-cell{width:184px;flex-basis:184px}
  .vision-pathway-goal{gap:18px}
}
@media(max-width:900px){
  .vision-pathway{--vision-goal-size:26px}
  .vision-pathway-map{grid-template-columns:max-content 68px max-content}
  .vision-pathway-source{gap:18px;padding-right:14px}
  .vision-pathway-cell{width:160px;flex-basis:160px}
  .vision-pathway-goal{gap:16px}
}
@media(max-width:860px){
  .vision-pathway{--vision-goal-size:25px;--vision-goal-leading:1.25;--vision-goal-tracking:-.5px;margin-top:36px;padding:20px 0 10px}
  .vision-pathway>figcaption{font-size:26px}
  .vision-pathway-map{width:100%;max-width:400px;grid-template-columns:56px minmax(0,1fr);row-gap:0;margin-top:28px;min-height:0;align-items:stretch}
  .vision-pathway-source{grid-column:1/-1;justify-content:center;gap:16px;padding:0 0 28px}
  .vision-pathway-source-copy>p{margin-top:9px;margin-bottom:7px;max-width:240px}
  .vision-pathway-label{font-size:10px}
  .vision-pathway-context{font-size:14px}
  .vision-pathway-cell{align-self:center;width:140px;flex-basis:140px}
  .vision-pathway-desktop-break{display:none}
  .vision-pathway-connector{grid-column:1;grid-row:2;height:auto;min-height:270px}
  .vision-pathway-connector .vision-pathway-fork-desktop{display:none}
  .vision-pathway-connector .vision-pathway-fork-mobile{display:block}
  .vision-pathway-goals{grid-column:2;grid-row:2;min-height:270px}
  .vision-pathway-goal{gap:18px;padding:14px 0}
  .vision-pathway-node{flex-basis:12px;width:12px;height:12px;box-shadow:0 0 0 4px #f8f5ee}
  .vision-pathway-goal h3{margin-top:7px;max-width:310px}
}
@media(max-width:360px){
  .vision-pathway{--vision-goal-size:23px}
  .vision-pathway-cell{width:110px;flex-basis:110px}
  .vision-pathway-source{gap:14px}
  .vision-pathway-goal{gap:12px}
}

/* Science: a concise introduction beside a vertical treatment sequence. */
.science.section-pad{min-height:calc(100svh - 68px);padding-block:clamp(80px,9svh,112px);display:flex;flex-direction:column;justify-content:center}
.science .section-kicker{margin-bottom:40px}
.science-intro{grid-template-columns:1.05fr 1fr;gap:clamp(64px,7vw,112px);align-items:center}
.science-copy{min-width:0}
.science-description{padding-top:52px}
.science-description .large-copy{font-size:21px;line-height:1.6;letter-spacing:-.25px;max-width:520px}
.science-description>p+p{font-size:16px;line-height:1.7;margin-top:20px;max-width:500px}
.science-tumour{width:96%;max-width:580px;margin-inline:auto;position:relative;container-type:inline-size;transform:translateX(-16px)}
.science-body-labels{position:absolute;inset:2.5% 0 auto;display:grid;grid-template-columns:repeat(3,minmax(0,1fr));font-size:clamp(12px,3.3cqw,16px);line-height:1.3;text-align:center;color:#654358;pointer-events:none}
.science-body-labels>span:last-child{color:#627286}
.science-tumour>figcaption{font-size:11px;font-weight:500;letter-spacing:.1em;line-height:1.5;text-transform:uppercase;color:#8a6073;margin-bottom:8px}
.science-tumour>svg{display:block;width:100%;height:auto;overflow:visible}
.science .science-points{grid-template-columns:1fr;gap:0;margin:0}
.science-points article{display:grid;grid-template-columns:34px minmax(0,1fr);column-gap:20px;padding:38px 0}
.science-points article:last-child{border-bottom:1px solid var(--line)}
.science .point-index{font-size:12px;padding-top:4px;grid-column:1;grid-row:1/3}
.science-points h3{grid-column:2;margin:0 0 12px;font-size:24px;line-height:1.3}
.science-points p{grid-column:2;font-size:15px;line-height:1.7;max-width:390px}
.science .science-bridge{display:grid;grid-template-columns:minmax(0,1fr) auto;align-items:end;gap:48px;margin-top:48px;padding-top:28px}
.science .science-bridge p{max-width:760px;font-size:clamp(23px,2vw,28px);line-height:1.4;letter-spacing:-.3px;color:var(--plum)}
.science-focus-label{display:block;margin-bottom:8px;font-size:14px;font-weight:500;line-height:1.5;letter-spacing:0;color:var(--muted)}
.science-bridge .text-link{justify-self:end;align-self:end;width:max-content;margin-top:0;margin-bottom:4px;white-space:nowrap}
@media(max-width:1050px){
  .science-intro{gap:52px}
  .science-description .large-copy{font-size:20px}
  .science-points article{grid-template-columns:28px minmax(0,1fr);column-gap:18px;padding:32px 0}
  .science-points h3{font-size:22px}
}
@media(max-width:760px){
  .science.section-pad{min-height:calc(100svh - 60px);padding-block:76px}
  .science .section-kicker{margin-bottom:30px}
  .science-intro{grid-template-columns:1fr;gap:40px}
  .science-description{padding-top:32px}
  .science-tumour-annotation text{font-size:24px}
  .science-description .large-copy{font-size:20px}
  .science-description>p+p{font-size:15px;margin-top:18px}
  .science-points article{padding-block:30px}
  .science-points h3{font-size:21px}
  .science-points p{font-size:14px;max-width:none}
  .science .science-bridge{grid-template-columns:1fr;gap:20px;margin-top:32px;padding-top:24px;border-top:0}
  .science .science-bridge p{font-size:23px}
  .science-bridge .text-link{justify-self:start;margin-bottom:0}
}
@media(max-width:480px){.science-tumour{width:100%}}
@media(max-width:360px){#science-title{font-size:clamp(36px,11.25vw,41px)}}

/* Give the approach explanation equal presence beside its headline. */
.approach-heading{align-items:center;gap:64px}
.approach-heading>p{font-size:clamp(20px,1.6vw,23px);line-height:1.6;max-width:600px}
@media(max-width:760px){.approach-heading{gap:30px}.approach-heading>p{font-size:18px;line-height:1.65;max-width:none}}

/* Main copy shares the science explanation's minimum size at every breakpoint. */
:root{--body-copy-size:15px}
.science-points p,
.synergy-activity-copy>span,
.synergy-instruction,
.team-role,
.team-bio,
.vision-pathway-context,
.contact-copy>p,
.contact-email,
#evidence-dialog>p,
.reference-list p,
.reference-sources a,
.science .science-bridge .text-link,
.hero.hero-video .button,
.contact .button{
  font-size:var(--body-copy-size);
}

/* Section and contact labels share a size below the main copy. */
.section-kicker,
.science .section-kicker,
.contact .eyebrow{font-size:13px}

/* Supporting pathway labels stay smaller than the explanatory context. */
.vision-pathway-label{font-size:12px}

/* Explanatory captions share the body-copy minimum. */
.science .point-index,
.dialog-head .eyebrow,
.reference-list li>span,
.science-focus-label,
.synergy-activity-number{
  font-size:var(--body-copy-size);
}
.science-body-labels{font-size:clamp(15px,3.3cqw,16px)}
/* Reserve room for labels that wrap above the mobile diagram. */
@media(max-width:760px){
  .science-tumour{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));transform:translateX(-8px)}
  .science-body-labels{position:static;grid-column:1/-1;grid-row:1}
  .science-body-labels>span{padding-inline:2px}
  .science-tumour>svg{grid-column:1/-1;grid-row:2}
}